Preheat your oven to 350°F (175°C).
In a large bowl, combine the ground beef, bread crumbs, milk, egg, onion, salt, black pepper, garlic powder, and onion powder. Mix until well combined.
Transfer the mixture into a loaf pan and shape it into a loaf.
In a small bowl, mix the ketchup, brown sugar, and mustard to create the glaze.
Spread the glaze evenly over the meatloaf.
Bake in the preheated oven for 1 hour, or until the meatloaf is cooked through and the internal temperature reaches 160°F (70°C).
Let the meatloaf rest for about 10 minutes before slicing and serving. Enjoy!