Preheat the oven to 325°F (163°C) and prepare a 9-inch springform pan.
In a bowl, combine the graham cracker crumbs, sugar, and melted butter. Press the mixture into the bottom of the springform pan and set aside.
In a large mixing bowl, beat the cream cheese and sugar until smooth and creamy.
Beat in the eggs one at a time, mixing well after each addition.
Stir in the Limoncello, vanilla extract, flour, and lemon zest until fully combined.
Pour the cream cheese mixture over the prepared crust in the springform pan.
Bake for 70 minutes or until the center is set, and the edges are lightly browned.
Allow the cheesecake to cool completely on a wire rack, then refrigerate for at least 4 hours before serving.