Preheat grill to medium-high heat.
In a bowl, combine ground beef, seasoned salt, garlic powder, and black pepper. Mix until well combined.
Divide the ground beef mixture into 8 equal portions. Flatten each portion into a thin patty.
Place a slice of pepper jack cheese in the center of 4 patties. Top with another patty and press the edges together to seal.
Grill the stuffed burgers for 5 minutes per side, or until cooked to your desired level of doneness.
Serve the burgers on toasted buns with lettuce, tomato, onion, and your favorite condiments.